The galaxy's ultimate hunter takes on the Earth's greatest champion in a battle that holds the fate of the world in the balance. While investigating a mysterious alien ship in the jungles of Central America, Superman becomes the victim of a power-draining virus. But when the Predator senses the arrival of a worthy opponent, the alien instantly targets the Man of Steel as his next prey. Now, a weakened and dazed Superman must find a way to defeat an unstoppable monster or witness the first step in the Predator's domination of Earth.