The Demon, Starchild, Beast King, and the Celestial probe the genetic mysteries behind the bizarre transformations of the young woman named Christine 16; meanwhile all Hell breaks loose across Manhattan as a storm of hideous monsters rains down on a terrified city. This monstrous maelstrom might be a bit much for even KISS to handle, but when has that ever stopped them from putting up a fight? Ever closer to unraveling the dark secrets of the Unholy- and restoring the lost humanity of the people he's victimized - The Four Who Are One embark on a mission of terrifying and apocalyptic proportions.